Clinical, Laboratory and Neuroimaging of Acquired Demyelinating Syndrome of the Children Admitted in a Tertiary Care Hospital in Bangladesh
Abstract:
Background: Acquired demyelinating syndrome (ADS) are
autoimmune inflammatory disorder affecting the white matter
of brain, optic nerve and spinal cord, and it has long been
unrecognized. Early diagnosis and proper management slow
the disease progression and reduce mortality and morbidity.
Objective: To find out the clinical, laboratory and
neuroimaging patterns of ADS in children in Bangladesh.
Materials and Methods: A cross-sectional study was conducted
from July 2020 to January 2021 in the Department of Pediatric
Neurology, National Institute of Neuroscience and Hospital,
including 37 children <18 years who had acute neurological
deficits and MRI evidence of demyelination. After
enrollment detailed history, physical examination, CSF study,
oligoclonal bands (OCBs), and anti-NMO antibody was
done and managed accordingly. Statistical analysis was done
using SPSS version 22.