Comparative Analysis of p53 Protein Expression in Early onset and Later-onset Colorectal Cancers
Background: The global incidence of early onset colorectal cancer (CRC) is rapidly rising. However the reason for this and genomic characteristics of early onset CRC is largely unknown. p53 mutation is common in CRC and has been linked to an increased risk of early onset CRC.
Materials & Methods: All CRC patients operated at Department of Surgical Oncology, NICRH, between October 1, 2021 and September 30, 2022 were included in this study. Demographic and clinical data and surgical findings were recorded. Histopathology and p53 immunohistochemistry (IHC) analysis was done. Patients were categorized in two groups ‘Early onset’ (diagnosed before 50 years of age) and ‘Late onset’ (diagnosed at or after 50 years of age). p53 protein IHC status (Mutant or Wild type) and other clinicopathological features were compared between the two groups.