Diagnostic Accuracy of Serum Ceruloplasmin in the Diagnosis of Pediatric Wilson’s Disease
Abstract:
Background: Wilson disease is a autosomal recessive disorder
of copper metabolism with diverse clinical manifestation.
Early diagnosis is crucial to prevent irreversible damage of
liver & brain. Serum ceruloplasmin is one of the major
diagnostic parameters for Wilson’s disease. Herein, we
evaluate diagnostic value of serum ceruloplasmin level for
Wilson disease in children up to age 15 year.
Materials & Methods: This case control study was conducted
from January 2016 to January 2019 in the department of
Paediatric Gastroenterology and Nutrition, Bangabandhu
Sheikh Mujib Medical University, Dhaka, Bangladesh.
Serum ceruloplasmin was measured in 103 WD patients
and 58 non-WD patients with other liver disease. Wilson
disease was diagnosed using the Leipzig score. Receiver
operating characteristics (ROC) curve was used to determine
the diagnostic accuracy of serum ceruloplasmin for WD in
children.