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Efficacy of Nivolumab in Comparison to Chemotherapy and Gefitinib for Advanced Non Small Cell Lung Cancer (NSCLC)

Abstract:

Background: Lung cancer is one of the major causes of cancer related death worldwide, while non-small cell lung cancer (NSCLC) consists of 85% of all lung cancer cases. Despite adequate treatment, most of the NSCLC patients progress to advance stages. Single or doublet-chemotherapy are considered as standard care for advance NSCLC patients. Gefitinib is considered as standard therapy for epidermal growth factor receptor (EGFR) mutant advanced NSCLC. Recently, a human monoclonal antibody called Nivolumab has shown encouraging efficacy for advanced NSCLC patients. The aim of this systematic review is to show the efficacy of nivolumab in comparison to single or doublet chemotherapy and gefitinib.

 

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Whoops! There was an error.
ErrorException (E_NOTICE)
fwrite(): write of 1887 bytes failed with errno=122 Disk quota exceeded ErrorException thrown with message "fwrite(): write of 1887 bytes failed with errno=122 Disk quota exceeded" Stacktrace: #13 ErrorException in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:131 #12 fwrite in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:131 #11 Monolog\Handler\StreamHandler:streamWrite in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php:117 #10 Monolog\Handler\StreamHandler:write in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/RotatingFileHandler.php:119 #9 Monolog\Handler\RotatingFileHandler:write in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php:39 #8 Monolog\Handler\AbstractProcessingHandler:handle in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:344 #7 Monolog\Logger:addRecord in /home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Logger.php:712 #6 Monolog\Logger:error in /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:176 #5 Illuminate\Log\Logger:writeLog in /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php:87 #4 Illuminate\Log\Logger:error in /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php:498 #3 Illuminate\Log\LogManager:error in /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php:114 #2 Illuminate\Foundation\Exceptions\Handler:report in /home1/bcpsjournal/public_html/app/Exceptions/Handler.php:37 #1 App\Exceptions\Handler:report in /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php:81 #0 Illuminate\Foundation\Bootstrap\HandleExceptions:handleException in [internal]:0
Application frames (1) All frames (14)
13
ErrorException
…/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php131
12
fwrite
…/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php131
11
Monolog\Handler\StreamHandler streamWrite
…/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php117
10
Monolog\Handler\StreamHandler write
…/vendor/monolog/monolog/src/Monolog/Handler/RotatingFileHandler.php119
9
Monolog\Handler\RotatingFileHandler write
…/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php39
8
Monolog\Handler\AbstractProcessingHandler handle
…/vendor/monolog/monolog/src/Monolog/Logger.php344
7
Monolog\Logger addRecord
…/vendor/monolog/monolog/src/Monolog/Logger.php712
6
Monolog\Logger error
…/vendor/laravel/framework/src/Illuminate/Log/Logger.php176
5
Illuminate\Log\Logger writeLog
…/vendor/laravel/framework/src/Illuminate/Log/Logger.php87
4
Illuminate\Log\Logger error
…/vendor/laravel/framework/src/Illuminate/Log/LogManager.php498
3
Illuminate\Log\LogManager error
…/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php114
2
Illuminate\Foundation\Exceptions\Handler report
…/app/Exceptions/Handler.php37
1
App\Exceptions\Handler report
…/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php81
0
Illuminate\Foundation\Bootstrap\HandleExceptions handleException
[internal]0
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
    protected function streamWrite($stream, array $record)
    {
        fwrite($stream, (string) $record['formatted']);
    }
 
    private function customErrorHandler($code, $msg)
    {
        $this->errorMessage = preg_replace('{^(fopen|mkdir)\(.*?\): }', '', $msg);
    }
 
    /**
     * @param string $stream
     *
     * @return null|string
     */
    private function getDirFromStream($stream)
    {
        $pos = strpos($stream, '://');
        if ($pos === false) {
            return dirname($stream);
        }
 
        if ('file://' === substr($stream, 0, 7)) {
Arguments 
  1. "fwrite(): write of 1887 bytes failed with errno=122 Disk quota exceeded"
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
    protected function streamWrite($stream, array $record)
    {
        fwrite($stream, (string) $record['formatted']);
    }
 
    private function customErrorHandler($code, $msg)
    {
        $this->errorMessage = preg_replace('{^(fopen|mkdir)\(.*?\): }', '', $msg);
    }
 
    /**
     * @param string $stream
     *
     * @return null|string
     */
    private function getDirFromStream($stream)
    {
        $pos = strpos($stream, '://');
        if ($pos === false) {
            return dirname($stream);
        }
 
        if ('file://' === substr($stream, 0, 7)) {
Arguments 
  1. stream resource @8
  timed_out: false
  blocked: true
  eof: false
  wrapper_type: "plainfile"
  stream_type: "STDIO"
  mode: "a"
  unread_bytes: 0
  seekable: true
  uri: "/home1/bcpsjournal/public_html/storage/logs/laravel-2024-11-21.log"
  options: []
}

  2. """
[2024-11-21 09:29:24] local.ERROR: file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded {"exception":"[object] (ErrorException(code: 0): file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded at /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
[stacktrace]\n
#0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(8, 'file_put_conten...', '/home1/bcpsjour...', 122, Array)\n
#1 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', 2)\n
#2 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', true)\n
#3 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('tfgiq8P5FNA89Nz...', 'a:3:{s:6:\"_toke...')\n
#4 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
#5 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
#6 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
#7 /home1/bcpsjournal/public_html/public/index.php(60): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
#8 {main}\n
"} \n
"""
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/StreamHandler.php 
            $this->createDir();
            $this->errorMessage = null;
            set_error_handler(array($this, 'customErrorHandler'));
            $this->stream = fopen($this->url, 'a');
            if ($this->filePermission !== null) {
                @chmod($this->url, $this->filePermission);
            }
            restore_error_handler();
            if (!is_resource($this->stream)) {
                $this->stream = null;
                throw new \UnexpectedValueException(sprintf('The stream or file "%s" could not be opened: '.$this->errorMessage, $this->url));
            }
        }
 
        if ($this->useLocking) {
            // ignoring errors here, there's not much we can do about them
            flock($this->stream, LOCK_EX);
        }
 
        $this->streamWrite($this->stream, $record);
 
        if ($this->useLocking) {
            flock($this->stream, LOCK_UN);
        }
    }
 
    /**
     * Write to stream
     * @param resource $stream
     * @param array $record
     */
    protected function streamWrite($stream, array $record)
    {
        fwrite($stream, (string) $record['formatted']);
    }
 
    private function customErrorHandler($code, $msg)
    {
        $this->errorMessage = preg_replace('{^(fopen|mkdir)\(.*?\): }', '', $msg);
    }
Arguments 
  1. stream resource @8
  timed_out: false
  blocked: true
  eof: false
  wrapper_type: "plainfile"
  stream_type: "STDIO"
  mode: "a"
  unread_bytes: 0
  seekable: true
  uri: "/home1/bcpsjournal/public_html/storage/logs/laravel-2024-11-21.log"
  options: []
}

  2. array:8 [
  "message" => "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  "context" => array:1 [
    "exception" => ErrorException {#400
      #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
      #code: 0
      #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_NOTICE
    }
  ]
  "level" => 400
  "level_name" => "ERROR"
  "channel" => "local"
  "datetime" => DateTime @1732181364 {#415
    date: 2024-11-21 09:29:24.175460 UTC (+00:00)
  }
  "extra" => []
  "formatted" => """
    [2024-11-21 09:29:24] local.ERROR: file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded {"exception":"[object] (ErrorException(code: 0): file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded at /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
    [stacktrace]\n
    #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(8, 'file_put_conten...', '/home1/bcpsjour...', 122, Array)\n
    #1 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', 2)\n
    #2 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', true)\n
    #3 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('tfgiq8P5FNA89Nz...', 'a:3:{s:6:\"_toke...')\n
    #4 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
    #5 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #6 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #7 /home1/bcpsjournal/public_html/public/index.php(60): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #8 {main}\n
    "} \n
    """
]
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/RotatingFileHandler.php 
        $this->url = $this->getTimedFilename();
        $this->close();
    }
 
    /**
     * {@inheritdoc}
     */
    protected function write(array $record)
    {
        // on the first record written, if the log is new, we should rotate (once per day)
        if (null === $this->mustRotate) {
            $this->mustRotate = !file_exists($this->url);
        }
 
        if ($this->nextRotation < $record['datetime']) {
            $this->mustRotate = true;
            $this->close();
        }
 
        parent::write($record);
    }
 
    /**
     * Rotates the files.
     */
    protected function rotate()
    {
        // update filename
        $this->url = $this->getTimedFilename();
        $this->nextRotation = new \DateTime('tomorrow');
 
        // skip GC of old logs if files are unlimited
        if (0 === $this->maxFiles) {
            return;
        }
 
        $logFiles = glob($this->getGlobPattern());
        if ($this->maxFiles >= count($logFiles)) {
            // no files to remove
            return;
Arguments 
  1. array:8 [
  "message" => "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  "context" => array:1 [
    "exception" => ErrorException {#400
      #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
      #code: 0
      #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_NOTICE
    }
  ]
  "level" => 400
  "level_name" => "ERROR"
  "channel" => "local"
  "datetime" => DateTime @1732181364 {#415
    date: 2024-11-21 09:29:24.175460 UTC (+00:00)
  }
  "extra" => []
  "formatted" => """
    [2024-11-21 09:29:24] local.ERROR: file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded {"exception":"[object] (ErrorException(code: 0): file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded at /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
    [stacktrace]\n
    #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(8, 'file_put_conten...', '/home1/bcpsjour...', 122, Array)\n
    #1 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', 2)\n
    #2 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', true)\n
    #3 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('tfgiq8P5FNA89Nz...', 'a:3:{s:6:\"_toke...')\n
    #4 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
    #5 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #6 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #7 /home1/bcpsjournal/public_html/public/index.php(60): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #8 {main}\n
    "} \n
    """
]
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Handler/AbstractProcessingHandler.php 
 *
 * @author Jordi Boggiano <j.boggiano@seld.be>
 * @author Christophe Coevoet <stof@notk.org>
 */
abstract class AbstractProcessingHandler extends AbstractHandler
{
    /**
     * {@inheritdoc}
     */
    public function handle(array $record)
    {
        if (!$this->isHandling($record)) {
            return false;
        }
 
        $record = $this->processRecord($record);
 
        $record['formatted'] = $this->getFormatter()->format($record);
 
        $this->write($record);
 
        return false === $this->bubble;
    }
 
    /**
     * Writes the record down to the log of the implementing handler
     *
     * @param  array $record
     * @return void
     */
    abstract protected function write(array $record);
 
    /**
     * Processes a record.
     *
     * @param  array $record
     * @return array
     */
    protected function processRecord(array $record)
    {
Arguments 
  1. array:8 [
  "message" => "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  "context" => array:1 [
    "exception" => ErrorException {#400
      #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
      #code: 0
      #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_NOTICE
    }
  ]
  "level" => 400
  "level_name" => "ERROR"
  "channel" => "local"
  "datetime" => DateTime @1732181364 {#415
    date: 2024-11-21 09:29:24.175460 UTC (+00:00)
  }
  "extra" => []
  "formatted" => """
    [2024-11-21 09:29:24] local.ERROR: file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded {"exception":"[object] (ErrorException(code: 0): file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded at /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
    [stacktrace]\n
    #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(8, 'file_put_conten...', '/home1/bcpsjour...', 122, Array)\n
    #1 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', 2)\n
    #2 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', true)\n
    #3 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('tfgiq8P5FNA89Nz...', 'a:3:{s:6:\"_toke...')\n
    #4 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
    #5 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #6 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #7 /home1/bcpsjournal/public_html/public/index.php(60): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #8 {main}\n
    "} \n
    """
]
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Logger.php 
        }
        $ts->setTimezone(static::$timezone);
 
        $record = array(
            'message' => (string) $message,
            'context' => $context,
            'level' => $level,
            'level_name' => $levelName,
            'channel' => $this->name,
            'datetime' => $ts,
            'extra' => array(),
        );
 
        try {
            foreach ($this->processors as $processor) {
                $record = call_user_func($processor, $record);
            }
 
            while ($handler = current($this->handlers)) {
                if (true === $handler->handle($record)) {
                    break;
                }
 
                next($this->handlers);
            }
        } catch (Exception $e) {
            $this->handleException($e, $record);
        }
 
        return true;
    }
 
    /**
     * Ends a log cycle and frees all resources used by handlers.
     *
     * Closing a Handler means flushing all buffers and freeing any open resources/handles.
     * Handlers that have been closed should be able to accept log records again and re-open
     * themselves on demand, but this may not always be possible depending on implementation.
     *
     * This is useful at the end of a request and will be called automatically on every handler
Arguments 
  1. array:8 [
  "message" => "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  "context" => array:1 [
    "exception" => ErrorException {#400
      #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
      #code: 0
      #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
      #line: 122
      #severity: E_NOTICE
    }
  ]
  "level" => 400
  "level_name" => "ERROR"
  "channel" => "local"
  "datetime" => DateTime @1732181364 {#415
    date: 2024-11-21 09:29:24.175460 UTC (+00:00)
  }
  "extra" => []
  "formatted" => """
    [2024-11-21 09:29:24] local.ERROR: file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded {"exception":"[object] (ErrorException(code: 0): file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded at /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:122)\n
    [stacktrace]\n
    #0 [internal function]: Illuminate\\Foundation\\Bootstrap\\HandleExceptions->handleError(8, 'file_put_conten...', '/home1/bcpsjour...', 122, Array)\n
    #1 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php(122): file_put_contents('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', 2)\n
    #2 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/FileSessionHandler.php(83): Illuminate\\Filesystem\\Filesystem->put('/home1/bcpsjour...', 'a:3:{s:6:\"_toke...', true)\n
    #3 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Store.php(129): Illuminate\\Session\\FileSessionHandler->write('tfgiq8P5FNA89Nz...', 'a:3:{s:6:\"_toke...')\n
    #4 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Session/Middleware/StartSession.php(87): Illuminate\\Session\\Store->save()\n
    #5 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(218): Illuminate\\Session\\Middleware\\StartSession->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #6 /home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Http/Kernel.php(189): Illuminate\\Foundation\\Http\\Kernel->terminateMiddleware(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #7 /home1/bcpsjournal/public_html/public/index.php(60): Illuminate\\Foundation\\Http\\Kernel->terminate(Object(Illuminate\\Http\\Request), Object(Illuminate\\Http\\Response))\n
    #8 {main}\n
    "} \n
    """
]
/home1/bcpsjournal/public_html/vendor/monolog/monolog/src/Monolog/Logger.php 
     * @param  array  $context The log context
     * @return bool   Whether the record has been processed
     */
    public function err($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the ERROR level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string $message The log message
     * @param  array  $context The log context
     * @return bool   Whether the record has been processed
     */
    public function error($message, array $context = array())
    {
        return $this->addRecord(static::ERROR, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
     *
     * @param  string $message The log message
     * @param  array  $context The log context
     * @return bool   Whether the record has been processed
     */
    public function crit($message, array $context = array())
    {
        return $this->addRecord(static::CRITICAL, $message, $context);
    }
 
    /**
     * Adds a log record at the CRITICAL level.
     *
     * This method allows for compatibility with common interfaces.
Arguments 
  1. 400

  2. "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"

  3. array:1 [
  "exception" => ErrorException {#400
    #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
    #code: 0
    #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
    #line: 122
    #severity: E_NOTICE
  }
]
/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php 
     * @return void
     */
    public function write($level, $message, array $context = [])
    {
        $this->writeLog($level, $message, $context);
    }
 
    /**
     * Write a message to the log.
     *
     * @param  string  $level
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    protected function writeLog($level, $message, $context)
    {
        $this->fireLogEvent($level, $message = $this->formatMessage($message), $context);
 
        $this->logger->{$level}($message, $context);
    }
 
    /**
     * Register a new callback handler for when a log event is triggered.
     *
     * @param  \Closure  $callback
     * @return void
     *
     * @throws \RuntimeException
     */
    public function listen(Closure $callback)
    {
        if (! isset($this->dispatcher)) {
            throw new RuntimeException('Events dispatcher has not been set.');
        }
 
        $this->dispatcher->listen(MessageLogged::class, $callback);
    }
 
    /**
Arguments 
  1. "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"

  2. array:1 [
  "exception" => ErrorException {#400
    #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
    #code: 0
    #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
    #line: 122
    #severity: E_NOTICE
  }
]
/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Log/Logger.php 
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log an error message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a warning message to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->writeLog(__FUNCTION__, $message, $context);
    }
 
    /**
     * Log a notice to the logs.
     *
     * @param  string  $message
     * @param  array  $context
     * @return void
Arguments 
  1. "error"

  2. "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"

  3. array:1 [
  "exception" => ErrorException {#400
    #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
    #code: 0
    #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
    #line: 122
    #severity: E_NOTICE
  }
]
/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Log/LogManager.php 
     *
     * @return void
     */
    public function critical($message, array $context = [])
    {
        $this->driver()->critical($message, $context);
    }
 
    /**
     * Runtime errors that do not require immediate action but should typically
     * be logged and monitored.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function error($message, array $context = [])
    {
        $this->driver()->error($message, $context);
    }
 
    /**
     * Exceptional occurrences that are not errors.
     *
     * Example: Use of deprecated APIs, poor use of an API, undesirable things
     * that are not necessarily wrong.
     *
     * @param string $message
     * @param array  $context
     *
     * @return void
     */
    public function warning($message, array $context = [])
    {
        $this->driver()->warning($message, $context);
    }
 
    /**
     * Normal but significant events.
Arguments 
  1. "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"

  2. array:1 [
  "exception" => ErrorException {#400
    #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
    #code: 0
    #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
    #line: 122
    #severity: E_NOTICE
  }
]
/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Exceptions/Handler.php 
     */
    public function report(Exception $e)
    {
        if ($this->shouldntReport($e)) {
            return;
        }
 
        if (method_exists($e, 'report')) {
            return $e->report();
        }
 
        try {
            $logger = $this->container->make(LoggerInterface::class);
        } catch (Exception $ex) {
            throw $e;
        }
 
        $logger->error(
            $e->getMessage(),
            array_merge($this->context(), ['exception' => $e]
        ));
    }
 
    /**
     * Determine if the exception should be reported.
     *
     * @param  \Exception  $e
     * @return bool
     */
    public function shouldReport(Exception $e)
    {
        return ! $this->shouldntReport($e);
    }
 
    /**
     * Determine if the exception is in the "do not report" list.
     *
     * @param  \Exception  $e
     * @return bool
     */
Arguments 
  1. "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"

  2. array:1 [
  "exception" => ErrorException {#400
    #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
    #code: 0
    #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
    #line: 122
    #severity: E_NOTICE
  }
]
/home1/bcpsjournal/public_html/app/Exceptions/Handler.php 
 
    /**
     * A list of the inputs that are never flashed for validation exceptions.
     *
     * @var array
     */
    protected $dontFlash = [
        'password',
        'password_confirmation',
    ];
 
    /**
     * Report or log an exception.
     *
     * @param  \Exception  $exception
     * @return void
     */
    public function report(Exception $exception)
    {
        parent::report($exception);
    }
 
    /**
     * Render an exception into an HTTP response.
     *
     * @param  \Illuminate\Http\Request  $request
     * @param  \Exception  $exception
     * @return \Illuminate\Http\Response
     */
    public function render($request, Exception $exception)
    {
        return parent::render($request, $exception);
    }
}
Arguments 
  1. ErrorException {#400
  #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  #code: 0
  #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
  #line: 122
  #severity: E_NOTICE
}
/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Foundation/Bootstrap/HandleExceptions.php 
    }
 
    /**
     * Handle an uncaught exception from the application.
     *
     * Note: Most exceptions can be handled via the try / catch block in
     * the HTTP and Console kernels. But, fatal error exceptions must
     * be handled differently since they are not normal exceptions.
     *
     * @param  \Throwable  $e
     * @return void
     */
    public function handleException($e)
    {
        if (! $e instanceof Exception) {
            $e = new FatalThrowableError($e);
        }
 
        try {
            $this->getExceptionHandler()->report($e);
        } catch (Exception $e) {
            //
        }
 
        if ($this->app->runningInConsole()) {
            $this->renderForConsole($e);
        } else {
            $this->renderHttpResponse($e);
        }
    }
 
    /**
     * Render an exception to the console.
     *
     * @param  \Exception  $e
     * @return void
     */
    protected function renderForConsole(Exception $e)
    {
        $this->getExceptionHandler()->renderForConsole(new ConsoleOutput, $e);
Arguments 
  1. ErrorException {#400
  #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  #code: 0
  #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
  #line: 122
  #severity: E_NOTICE
}
[internal]
Arguments 
  1. ErrorException {#400
  #message: "file_put_contents(): write of 310 bytes failed with errno=122 Disk quota exceeded"
  #code: 0
  #file: "/home1/bcpsjournal/public_html/vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php"
  #line: 122
  #severity: E_NOTICE
}

Environment & details:

empty
empty
empty
empty
empty
Key Value
LSPHP_ENABLE_USER_INI 
"on"
PATH 
"/usr/local/bin:/usr/bin:/bin"
TEMP 
"/tmp"
TMP 
"/tmp"
TMPDIR 
"/tmp"
PWD 
"/"
HTTP_ACCEPT 
"*/*"
HTTP_ACCEPT_ENCODING 
"gzip, br, zstd, deflate"
CONTENT_LENGTH 
"0"
HTTP_HOST 
"bcpsjournal.org"
HTTP_USER_AGENT 
"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)"
HTTP_X_HTTPS 
"1"
REDIRECT_REDIRECT_UNIQUE_ID 
"Zz79dPMYhRfY97CTCF61RwABcGE"
REDIRECT_REDIRECT_QS_ConnectionId 
"173218136403793505962654"
REDIRECT_REDIRECT_SCRIPT_URL 
"/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
REDIRECT_REDIRECT_SCRIPT_URI 
"https://bcpsjournal.org/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
REDIRECT_REDIRECT_HTTPS 
"on"
REDIRECT_REDIRECT_SSL_TLS_SNI 
"bcpsjournal.org"
REDIRECT_REDIRECT_HTTP2 
"on"
REDIRECT_REDIRECT_H2PUSH 
"off"
REDIRECT_REDIRECT_H2_PUSH 
"off"
REDIRECT_REDIRECT_H2_PUSHED 
""
REDIRECT_REDIRECT_H2_PUSHED_ON 
""
REDIRECT_REDIRECT_H2_STREAM_ID 
"3"
REDIRECT_REDIRECT_H2_STREAM_TAG 
"962654-1005-3"
REDIRECT_REDIRECT_STATUS 
"200"
REDIRECT_UNIQUE_ID 
"Zz79dPMYhRfY97CTCF61RwABcGE"
REDIRECT_QS_ConnectionId 
"173218136403793505962654"
REDIRECT_SCRIPT_URL 
"/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
REDIRECT_SCRIPT_URI 
"https://bcpsjournal.org/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
REDIRECT_HTTPS 
"on"
REDIRECT_SSL_TLS_SNI 
"bcpsjournal.org"
REDIRECT_HTTP2 
"on"
REDIRECT_H2PUSH 
"off"
REDIRECT_H2_PUSH 
"off"
REDIRECT_H2_PUSHED 
""
REDIRECT_H2_PUSHED_ON 
""
REDIRECT_H2_STREAM_ID 
"3"
REDIRECT_H2_STREAM_TAG 
"962654-1005-3"
REDIRECT_STATUS 
"200"
UNIQUE_ID 
"Zz79dPMYhRfY97CTCF61RwABcGE"
QS_ConnectionId 
"173218136403793505962654"
SCRIPT_URL 
"/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
SCRIPT_URI 
"https://bcpsjournal.org/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
HTTPS 
"on"
SSL_TLS_SNI 
"bcpsjournal.org"
HTTP2 
"on"
H2PUSH 
"off"
H2_PUSH 
"off"
H2_PUSHED 
""
H2_PUSHED_ON 
""
H2_STREAM_ID 
"3"
H2_STREAM_TAG 
"962654-1005-3"
SERVER_SIGNATURE 
""
SERVER_SOFTWARE 
"Apache"
SERVER_NAME 
"bcpsjournal.org"
SERVER_ADDR 
"192.185.140.108"
SERVER_PORT 
"443"
REMOTE_ADDR 
"3.144.31.86"
DOCUMENT_ROOT 
"/home1/bcpsjournal/public_html"
REQUEST_SCHEME 
"https"
CONTEXT_PREFIX 
""
CONTEXT_DOCUMENT_ROOT 
"/home1/bcpsjournal/public_html"
SERVER_ADMIN 
"webmaster@bcpsjournal.org"
SCRIPT_FILENAME 
"/home1/bcpsjournal/public_html/public/index.php"
REMOTE_PORT 
"10167"
REDIRECT_URL 
"/public/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
SERVER_PROTOCOL 
"HTTP/2.0"
REQUEST_METHOD 
"GET"
QUERY_STRING 
""
REQUEST_URI 
"/journal-details/efficacy-of-nivolumab-in-comparison-to-chemotherapy-and-gefitinib-for-advanced-non-small-cell-lung-cancer-nsclc"
SCRIPT_NAME 
"/public/index.php"
PHP_SELF 
"/public/index.php"
REQUEST_TIME_FLOAT 
1732181364.0518
REQUEST_TIME 
1732181364
argv 
[]
argc 
0
APP_NAME 
"Laravel"
APP_ENV 
"local"
APP_KEY 
"base64:niSS5FWDNwT7pudPDTq5NyRiJZTGVD7s6t6jVaQXAGY="
APP_DEBUG 
"true"
APP_URL 
"http://localhost"
LOG_CHANNEL 
"stack"
DB_CONNECTION 
"mysql"
DB_HOST 
"127.0.0.1"
DB_PORT 
"3306"
DB_DATABASE 
"bcpsjour_laravel"
DB_USERNAME 
"bcpsjour_laravel"
DB_PASSWORD 
"bcpsjour_laravel"
BROADCAST_DRIVER 
"log"
CACHE_DRIVER 
"file"
QUEUE_CONNECTION 
"sync"
SESSION_DRIVER 
"file"
SESSION_LIFETIME 
"120"
REDIS_HOST 
"127.0.0.1"
REDIS_PASSWORD 
"null"
REDIS_PORT 
"6379"
MAIL_DRIVER 
"smtp"
MAIL_HOST 
"smtp.mailtrap.io"
MAIL_PORT 
"2525"
MAIL_USERNAME 
"a17a19b50cbf67"
MAIL_PASSWORD 
"aa018c2abec954"
MAIL_ENCRYPTION 
"null"
PUSHER_APP_ID 
""
PUSHER_APP_KEY 
""
PUSHER_APP_SECRET 
""
PUSHER_APP_CLUSTER 
"mt1"
MIX_PUSHER_APP_KEY 
""
MIX_PUSHER_APP_CLUSTER 
"mt1"
Key Value
APP_NAME 
"Laravel"
APP_ENV 
"local"
APP_KEY 
"base64:niSS5FWDNwT7pudPDTq5NyRiJZTGVD7s6t6jVaQXAGY="
APP_DEBUG 
"true"
APP_URL 
"http://localhost"
LOG_CHANNEL 
"stack"
DB_CONNECTION 
"mysql"
DB_HOST 
"127.0.0.1"
DB_PORT 
"3306"
DB_DATABASE 
"bcpsjour_laravel"
DB_USERNAME 
"bcpsjour_laravel"
DB_PASSWORD 
"bcpsjour_laravel"
BROADCAST_DRIVER 
"log"
CACHE_DRIVER 
"file"
QUEUE_CONNECTION 
"sync"
SESSION_DRIVER 
"file"
SESSION_LIFETIME 
"120"
REDIS_HOST 
"127.0.0.1"
REDIS_PASSWORD 
"null"
REDIS_PORT 
"6379"
MAIL_DRIVER 
"smtp"
MAIL_HOST 
"smtp.mailtrap.io"
MAIL_PORT 
"2525"
MAIL_USERNAME 
"a17a19b50cbf67"
MAIL_PASSWORD 
"aa018c2abec954"
MAIL_ENCRYPTION 
"null"
PUSHER_APP_ID 
""
PUSHER_APP_KEY 
""
PUSHER_APP_SECRET 
""
PUSHER_APP_CLUSTER 
"mt1"
MIX_PUSHER_APP_KEY 
""
MIX_PUSHER_APP_CLUSTER 
"mt1"
0. Whoops\Handler\PrettyPageHandler