First Ever Pediatric Allogeneic Hematopoietic Stem Cell Transplantation In A Transfusion Dependent Thalassemia Patient In Bangladesh- A Case Report With 17 Months Post-Transplant Follow Up
Background: Hematopoietic stem cell transplantation (HSCT) is the mainstay of treatment for many disease conditions. The first allogeneic HSCT was done by E. Donnall Thomas which was reported in the New England Journal of Medicine in September 1957. In that study six patients of Acute Leukemia were treated with radiation and chemotherapy followed by intravenous infusion of marrow from a normal donor where only two patients were engrafted but all died within 100 days of transplantation. In 1979 Thomas applied allogeneic HSCT earlier in the course of acute leukemia and reported a 50% cure rate in AML patients transplanted after first remission. In Bangladesh there was no scope of HSCT for thalassemia patients. The first ever pediatric allogeneic HSCT in a transfusion dependent thalassemia patient was performed in BMT center of CMH Dhaka on 30 November 2021. Here the case is reported with 17 months post-transplant follow up.