Pediatric Onset Myelin Oligodendrocyte Glycoprotein- Associated Disease: A Series of Four Cases
Abstract
Myelin oligodendrocyte glycoprotein (MOG) antibodyassociated
disease (MOG-AD) is a rare inflammatory
demyelinating disease of the central nervous system with
monophasic and relapsing manifestations. The most common
presenting phenotypes of MOG-AD in pediatric population
include acute disseminated encephalomyelitis (ADEM), optic
neuritis (ON), transverse myelitis (TM) and brainstem
syndromes. Here, we report four cases of MOG-AD in pediatric
patients. Patients presented with headache, gait disorder,
dysarthria, seizure. The first case had weakness of both lower
limbs with irritability, 2nd case had altered conscious level
with seizure along with walking and speech difficulty.